Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Authors
Ali, A Aster, SD Graham, DW Patel, GF Taylor, GE Tolman, RL Painter, RE Silver, LL Young, K Ellsworth, K Geissler, W Harris, GS
Citation
A. Ali et al., Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III, BIOORG MED, 11(16), 2001, pp. 2185-2188
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2185 - 2188
Database
ISI
SICI code
0960-894X(20010820)11:16<2185:DASONA>2.0.ZU;2-#
Abstract
4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selectiv e inhibitors of DNA polymerase III, a replicative enzyme known to be essent ial in the DNA synthesis of Gram-positive bacteria. Among the analogues. 18 displayed an IC50 of 10 muM against DNA polymerase III from Staphylococcus aureus. (C) 2001 Elsevier Science Ltd. All rights reserved.