Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone

Authors
Milic, DR Kop, T Juranic, Z Gasic, MJ Solaja, BA
Citation
Dr. Milic et al., Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone, BIOORG MED, 11(16), 2001, pp. 2197-2200
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2197 - 2200
Database
ISI
SICI code
0960-894X(20010820)11:16<2197:SAAAOE>2.0.ZU;2-Q
Abstract
Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X. HeLa and K-562 cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series. (C) 2001 Elsevier Science Ltd. All rights reserved.