Identification of selective inhibitors of cyclin dependent kinase 4

Authors
Carini, DJ Kaltenbach, RF Liu, J Benfield, PA Boylan, J Boisclair, M Brizuela, L Burton, CR Cox, S Grafstrom, R Harrison, BA Harrison, K Akamike, E Markwalder, JA Nakano, Y Seitz, SP Sharp, DM Trainor, GL Sielecki, TM
Citation
Dj. Carini et al., Identification of selective inhibitors of cyclin dependent kinase 4, BIOORG MED, 11(16), 2001, pp. 2209-2211
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2209 - 2211
Database
ISI
SICI code
0960-894X(20010820)11:16<2209:IOSIOC>2.0.ZU;2-J
Abstract
A new structural type of kinase inhibitor. containing a benzocarbazole nucl eus, has been identified. Members of the series are selective for inhibitio n of the cyclin dependent kinase family of enzymes. Although the cdks are h ighly homologous, representatives of the series showed intra-cdk selectivit ies, especially for cdk4. SAR studies elucidated the important features of the molecules for inhibition. (C) 2001 DuPont Pharmaceuticals Company. Publ ished by Elsevier Science Ltd. All rights reserved.