Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset

During the innate immune response to infection, monocyte-derived cytokines (monokines), stimulate natural killer (NK) cells to produce immunoregulator y cytokines that are important to the host's early defense. Human NK cell s ubsets can be distinguished by CD56 surface density expression (ie, CD56 bl ight and CD56(dim)). In this report, it is shown that CD56(bright) NK cells produce significantly greater levels of interferon-gamma, tumor necrosis f actor-beta, granulocyte macrophage-colony-stimulating factor, IL-10, and IL -13 protein in response to monokine stimulation than do CD56(dim) NK cells, which produce negligible amounts of these cytokines. Further, qualitative differences in CD56(bright) NK-derived cytokines are shown to be dependent on the specific monokines present. For example, the monokine IL-15 appears to be required for type 2 cytokine production by CD56(bright) NK cells. It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immu noregulatory cytokines, regulated in part by differential monokine producti on. (Blood. 2001;97:3146-3151) (C) 2001 by The American Society of Hematolo gy.