Mm. Rahman et al., Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial, BR MED J, 323(7308), 2001, pp. 314-318
Citations number
28
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Objective To evaluate the effect of simultaneous zinc and vitamin A supplem
entation on diarrhoea and acute lower respiratory infections in children.
Study design Randomised double blind placebo controlled trial.
Setting Urban slums of Dhaka, Bangladesh.
Participants and methods 800 children aged 12-35 months were randomly assig
ned to one of four intervention groups: 20 mg zinc once daily for 14 days;
200 000 IU vitamin A, single dose on day 14; both zinc and vitamin A; place
bo. The children were followed up once a week for six months, and morbidity
information was collected.
Results The incidence and prevalence of diarrhoea were lower in the zinc an
d vitamin A groups than in the placebo group. Zinc and vitamin A interactio
n had a rate ratio (95% confidence interval) of 0.79 (0.66 to 0.94) for the
prevalence of persistent diarrhoea and 0.80 (0.67 to 0.95) for dysentery.
Incidence (1.62; 1.16 to 2.25) and prevalence (2.07; 1.76 to 2.44) of acute
lower respirator,,, infection were significantly higher in the zinc group
than in the placebo group. The interaction term had rate ratios of 0.75 (0.
46 to 1.20) for incidence and 0.58 (0.46 to 0.73) for prevalence of acute l
ower respiratory infection.
Conclusions Combined zinc and vitamin A synergistically reduced the prevale
nce of persistent diarrhoea and dysentery. Zinc was associated with a signi
ficant increase in acute lower respiratory infection, but this adverse effe
ct was reduced by the interaction between zinc and vitamin A.