Status of current clinical trials in diabetic polyneuropathy

Peripheral polyneuropathy is the most frequent complication of diabetic mel litus. In spite of many clinical trials of different specific interventions for diabetic polyneuropathy, intensive glycemic control remains the only e ffective specific therapy currently available for this troublesome complica tion. This systematic overview reports the status of current clinical trial s in diabetic polyneuropathy with an emphasis on those interventions direct ed towards specific pathophysiological derangements. A discussion of clinic al trials of agents directed towards relieving painful symptoms of diabetic polyneuropathy concludes this overview.