The peripheral vascular response to exercise is impaired in patients with risk factors for coronary artery disease

Background: Abnormal coronary and brachial artery responses have been descr ibed in individuals with risk factors for coronary artery disease (CAD). Pe ripheral arterial tonometry (PAT), a newly developed digital plethysmograph ic technique was used to assess peripheral vascular response to exercise in healthy controls and individuals with risk factors. Methods and Results: C ontinuous finger PAT during Bruce protocol exercise test was performed in 3 0 subjects with risk factors for CAD and 30 healthy individuals. Compared w ith baseline, the PAT wave amplitude at peak exercise decreased in the subj ects but increased in the controls: 83 +/- 28% vs. 114 +/- 40% respectively , p < 0.01. Conclusions: A different pattern of systemic vascular response to exercise was found in individuals with risk factors for atherosclerosis. Since the vascular behavior in these patients is probably related to endot helial dysfunction, it may be that peripheral arterial tonometry can be use d as a simple, readily available technique to assess endothelial function. Copyright (C) 2001 S. Karger AG, Basel.