CHRONIC DIAZEPAM EXPOSURE DECREASES TRANSCRIPTION OF THE RAT GABA(A) RECEPTOR GAMMA(2)-SUBUNIT GENE

Authors
HOLT RA MARTIN IL BATESON AN
Citation
Ra. Holt et al., CHRONIC DIAZEPAM EXPOSURE DECREASES TRANSCRIPTION OF THE RAT GABA(A) RECEPTOR GAMMA(2)-SUBUNIT GENE, Molecular brain research, 48(1), 1997, pp. 164-166
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
48
Issue
1
Year of publication
1997
Pages
164 - 166
Database
ISI
SICI code
0169-328X(1997)48:1<164:CDEDTO>2.0.ZU;2-O
Abstract
The rate of transcription of the GABA(A) receptor gamma(2)-subunit gen e in rat cortex has been measured using the nuclear run-off transcript ional assay. Exposure of rats to diazepam (15 mg/kg/day for 14 days) c aused a significant reduction in the level of nascent GABA(A) receptor gamma(2)-subunit transcripts. Therefore, a component of the cellular response to chronic benzodiazepine exposure includes events which take place at the level of transcription of a GABA(A) receptor gene.