Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals

Authors
Mathema, B Cross, E Dun, E Park, S Bedell, J Slade, B Williams, M Riley, L Chaturvedi, V Perlin, DS
Citation
B. Mathema et al., Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals, CLIN INF D, 33(5), 2001, pp. E23-E27
Citations number
28
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
33
Issue
5
Year of publication
2001
Pages
E23 - E27
Database
ISI
SICI code
1058-4838(200109)33:5<E23:POVCBD>2.0.ZU;2-8
Abstract
We enrolled 382 college-age women in a cross-sectional survey to investigat e the relationship between use of over-the-counter (OTC) azole-based antifu ngal drugs and vaginal colonization by drug-resistant Candida. This study s howed no correlation (P = .506) between previous OTC exposure and colonizat ion of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.