Background The purpose of the present study is to determine whether airway
pressure release ventilation (APRV) can safely enhance hemodynamics in pati
ents with acute lung injury (ALI) and/or adult respiratory distress syndrom
e (ARDS), relative to pressure control ventilation (PCV).
Methods Patients with severe acute lung injury or ARDS who were managed wit
h inverse-ratio pressure control ventilation, neuromuscular blockade and a
pulmonary artery catheter were switched to APRV. Hemodynamic performance, a
s well as pressor and sedative needs, was assessed after discontinuing neur
omuscular blockade
Results Mean age was 58 +/- 9 years (n = 12) and mean Lung Injury Score was
7.6 +/- 2.1. Temperature and arterial oxygen tension/fractional inspired o
xygen (FiO(2)) were similar among the patients. Peak airway pressures fell
from 38 +/- 3 for PCV to 25 +/- 3 cmH(2)O for APRV, and mean pressures fell
from 18 +/- 3 for PCV to 12 +/- 2 cmH(2)O for APRV. Paralytic use and seda
tive use were significantly lower with APRV than with PCV. Pressor use decr
eased substantially with ARPV. Lactate levels remained normal, but decrease
d on APRV. Cardiac index rose from 3.2 +/- 0.4 for PCV to 4.6 +/- 0.3 l/min
per m(2) body surface area (BSA) for APRV, whereas oxygen delivery increas
ed from 997 +/- 108 for PCV to 1409 +/- 146 ml/min for APRV, and central ve
nous pressure declined from 18 +/- 4 for PCV to 12 +/- 4 cmH(2)O for APRV.
Urine output increased from 0.83 +/- 0.1 for PCV to 0.96 +/- 0.12 ml/kg per
hour for APRV.
Conclusion APRV may be used safely in patients with ALI/ARDS, and decreases
the need for paralysis and sedation as compared with PCV-inverse ratio ven
tilation (IRV). APRV increases cardiac performance, with decreased pressor
use and decreased airway pressure, in patients with ALI/ARDS.