Whether hormetic responses result from a direct or an overcompensation type
of stimulatory response has been an unresolved and contentious issue in bo
th radiation and chemical toxicology. The goal of the present article is to
identify numerous examples of overcompensation stimulation in the biologic
al/biomedical literature and to evaluate their descriptive and quantitative
features. The findings provide support for the hypothesis that hormetic do
se-response relationships from a broad array of biological models can occur
after an initial disruption in homeostasis. The finding also demonstrates
the significant role of temporal factors in the assessment of dose response
relationships.