Apoptosis: Biphasic dose responses

Authors
Citation
Ej. Calabrese, Apoptosis: Biphasic dose responses, CR R TOXIC, 31(4-5), 2001, pp. 607-613
Citations number
19
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CRITICAL REVIEWS IN TOXICOLOGY
ISSN journal
10408444 → ACNP
Volume
31
Issue
4-5
Year of publication
2001
Pages
607 - 613
Database
ISI
SICI code
1040-8444(2001)31:4-5<607:ABDR>2.0.ZU;2-U
Abstract
The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic re sponses. The present article specifically addresses the dose-response relat ionship for apoptosis in detail. It was determined that a number of well-do cumented cases exist in which the dose-response relationship for apoptosis is biphasic. The underlying mechanisms and biomedical implications of this biphasic dose-response phenomenon are discussed.