Emerging principles of de novo catalyst design

Considerable progress has been made in the understanding of how to exploit hydrophobic and charge-charge interactions in forming binding sites for pep tides and small molecules in folded polypeptide catalysts. This knowledge h as enabled the introduction of feedback and control functions into catalyti c cycles and the construction of folded polypeptide catalysts that follow s aturation kinetics. Major advances have also been made in the design of met alloproteins and metallopeptides, especially with regards to understanding redox potential control.