The application of non-combinatorial chemistry to lead discovery

Non-combinatorial chemistry is a powerful technology for the synthesis of l arge numbers of compounds, with complete control over the properties of tho se compounds. We have developed a Library Creation, Registration and Automa tion system (LiCRA), which harnesses an efficient noncombinatorial chemistr y design and synthesis engine, together with high-throughput automated puri fication. This LiCRA system also operates in a closed loop mode for hit-to- lead optimization, and contains an integrated IT system that controls and f acilitates all aspects of the operation from design to registration. Qualit y has been our watchword, from the quality of compound design through to th e quality of the products.