Potential impact of magnetic resonance cholangiopancreatography on endoscopic retrograde cholangiopancreatography workload and complication rate in patients referred because of abdominal pain

Background and Study Aims: Endoscopic retrograde cholangiopancreatography ( ERCP) has a significant mortality, morbidity, and failed cannulation rate. Magnetic resonance cholanglopancreatography (MRCP) is a safer, noninvasive method of imaging the pancreaticobiliary tree. A substantial number of pati ents are referred for ERCP because of abdominal pain, a high proportion of whom have normal ducts or pathology not requiring interventional ERCP. The aim was to assess the potential impact of MRCP on overall ERCP workload and patient outcome if MRCP were the primary,investigation in patients referre d for ERCP because of abdominal pain. Patients and Methods: 1758 consecutive ERCPs performed in 1148 patients ove r a 3-year period in a single tertiary referral center in the pre-MRCP era were reviewed. Cannulation failure, ERCP findings, need for follow-up ERCP and all 30-day major complication rates were analyzed with regard to clinic al indications. Results: The overall workload comprised 1108 (63%) successful initial ERCPs , 188 (11 %) failed cannulation attempts and 462 (26%) follow-up ERCPs. Of the patients, 299 (27%) had normal ERCP findings, 331 (30 %) had choledocho lithiasis and 246 (22 %) had strictures. If MRCP had been used as the prima ry imaging investigation in the 451 patients (39 %) referred for ERCP becau se of abdominal pain, we estimate that 197 patients (44 %) would have avoid ed ERCP, and the overall ERCP workload would have been reduced by 13 %. Ini tial MRCP in suspected gallstone pancreatitis and certain miscellaneous gro ups, it was estimated, would have further decreased ERCP workload by 9 %. F our of 40 major ERCP-related complications (3.5 %) and one of four ERCP-rel ated deaths (0.35 %) would potentially have been avoided. Conclusions: Initial MRCP in patients referred with abdominal pain would po tentially have avoided ERCP in 44 % of cases, reduced ERCP workload by, 13 % and significantly reduced patient morbidity, and mortality. The relativel y small reduction in ERCP workload among these patients reflects the fact t hat over half of them had probable sphincter dysfunction, a significant pro portion of whom might have benefited from biliary manometry and/or endoscop ic intervention despite a normal MRCP. Furthermore, a small number of patie nts with calculi and subtle biliary and pancreatic strictures would be miss ed by this approach.