P. Ten Holte et al., Synthesis of oxazolidinones by a solid-phase/activation cycloelimination (SP/ACE) methodology, EUR J ORG C, (15), 2001, pp. 2965-2969
A versatile method for the solid-phase synthesis of oxazolidinones is descr
ibed, An appropriate 1,2-diol is attached to immobilized sulfonyl chloride,
resulting in the selective activation of one of the alcohol functions, The
subsequent reaction of the other alcohol group with an isocyanate, followe
d by a base-promoted cycloelimination gives an oxazolidinone, By proper cho
ice of isocyanates, functionalities can be introduced which are essential f
or antibiotic activity.