Patency following successful thrombolysis of occluded vascular grafts

Aim: to determine patency after successful lysis of occluded bypass grafts. Methods: data were collected from four centres with a wide experience of th rombolysis. Outcome following successful lysis was determined from prospect ively collected data or case notes. Data from 75 patients, 53 men, were ana lysed. Results: median age at time of lysis was 68 years (range 33-88). Median age of graft was 12 months (range 1-120). Patency at 12 months was 33% (95% co nf. interval: 21-44%). There were no differences in patency depending on wh ether the graft was above or below the inguinal ligament or whether an addi tional procedure eg. percutaneous or vein patch angioplasty was carried out . However in those 48 cases when lysis was deemed complete, i.e. there was restoration of graft patency and at least one vessel run off patency at 12 months was 39% compared with 17% if lysis was incomplete (p = 0.04). Conclusions: at the present time it is difficult to justify routine thrombo lysis of occluded grafts when patency, based on intention to treat, is appr oximately 20% at one year. Following successful graft lysis the role of ant icoagulation and careful graft surveillance require further investigation.