A prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection

Objective: To compare the karyotype of babies conceived through ICSI with t hat of naturally conceived babies. Design: Prospective controlled study. Setting: The Egyptian IVF-ET Center, Cairo, Egypt. Patient(s): Four hundred and thirty babies conceived through ICSI and 430 b abies conceived naturally. Intervention(s): ICSI and karyotyping. Main Outcome Measure(s): Abnormal karyotype. Result(s): Four hundred and thirty consecutive babies conceived through ICS I who were delivered in one hospital had 15 abnormal karyotypes (3.5%). Of the 15 babies, 7 were of female phenotype and 8 of male phenotype. Six babi es had sex chromosome anomalies, 8 had autosomal anomalies, and I had combi ned sex chromosome and autosomal anomalies. A control group of 430 consecut ive babies conceived naturally who were delivered in one hospital had no ab normal karyotype. The difference between the two groups was significant (P < .001). Conclusion(s): ICSI carries a small but significant increased risk of abnor mal karyotyping to the offspring. This risk appears to be equally distribut ed between autosomal and sex chromosome anomalies. (C) 2001 by American Soc iety for Reproductive Medicine.