MICROPLATE READER - A CONVENIENT TOOL IN STUDIES OF BLOOD-COAGULATION

Results of platelet aggregation measured with a dual channel aggregome ter and with a microplate reader are compared. Platelets in plasma wer e activated by ADP and by collagen, and thrombin was used for the aggr egation study of gel filtered platelets. The results obtained with bot h instruments were quantitatively and qualitatively similar. A micropl ate reader allowed a simultaneous measurement of a high number of samp les with a high degree of reproducibility. The same instrument can be useful in other coagulology studies. Results of citrated plasma clotti ng by thrombin or by recalcination together with results of platelet c ounting, both obtained with a microplate reader, are presented in this report as well. (C) 1997 Elsevier Science Ltd.