Purpose: To study the influence of stereoscopic depth perception on automob
ile driving performance. Methods: Ten patients with strabismus and defectiv
e stereopsis were compared with ten healthy controls with respect to their
performance in a series of automobile driving manoeuvres. The two groups we
re individually matched as to age, annual miles driven, years of licence ho
lding and type of vehicle owned. After an ophthalmologic examination the su
bjects in each group performed the following series of driving tests: (1) s
topping in front of an obstacle, (2) reversing into a parking space, (3) dr
iving through a slalom course, (4) estimating the relative positions of two
cars. All tests were performed binocularly and monocularly (with the non-d
ominant eye covered). Results: Only in the slalom test did the normal subje
cts perform significantly better than the stereo-deficient subjects (odds r
atio 10.5; P<0.01). In estimating position, normal subjects actually perfor
med significantly worse (odds ratio 0.091; P<0.01). A significant distance
ratio of 2.5 (95% CI 1.1-5.5; P=0.033) of the monocular with respect to the
binocular performance of the normal subjects was found for the stopping ta
sk only, while the subjects with defective stereopsis showed no difference
between their monocular and binocular performance. Conclusion: In this stud
y, stereopsis had a positive effect on driving performance only in dynamic
situations at intermediate distances.