Evaluation of tiapride in agitated elderly outpatients: an open study

Authors
Citation
M. Tsolaki, Evaluation of tiapride in agitated elderly outpatients: an open study, HUM PSYCHOP, 16(5), 2001, pp. 417-422
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN journal
08856222 → ACNP
Volume
16
Issue
5
Year of publication
2001
Pages
417 - 422
Database
ISI
SICI code
0885-6222(200107)16:5<417:EOTIAE>2.0.ZU;2-B
Abstract
The aim of this study was the evaluation of the efficacy and safety of tiap ride 50-100 mg administered 3 times a day to elderly patients with aggressi ve behavior. Data from 425 questionnaires concerning aggressive behavior in Greek elderly patients were evaluated before and after treatment. The Brie f Agitation Rating Scale (BARS), which has 10 items, was used to evaluate t he effectiveness of tiapride. To test the overall effectiveness of the drug during the trial, the statistical method of repeated measures ANOVA was ap plied to the total score and the very small F-value (p < 0.0005) led us to accept the hypothesis that tiapride significantly improves the condition of elderly patients with aggressive behavior. Only 6.2% of patients developed an adverse event during the trial. With 95% probability one may state that the probability of an adverse event occurring during the administration of tiapride is between 5% and 7.4%. We conclude that tiapride, apart from bei ng very efficient in ameliorating aggressive behavior in elderly patients, is also very safe to administer. Copyright <(c)> 2001 John Wiley & Sons, Lt d.