Murine natural killer cell activation receptors

Natural killer (NK) cells express two types of receptors involved in target recognition: inhibitory receptors for target cell MHC class I molecules an d activation receptors. While there has been significant progress in unders tanding the inhibitory receptors, less is known about the activation recept ors. Detailed analysis of several mouse NK-cell activation receptors provid es insight into the physiologic relevance of these receptors in the innate immune response.