Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia

Authors
Olszyna, DP Pajkrt, D van Deventer, SJH van der Poll, T
Citation
Dp. Olszyna et al., Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia, IMMUNOL LET, 78(1), 2001, pp. 41-44
Citations number
18
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY LETTERS
ISSN journal
01652478 → ACNP
Volume
78
Issue
1
Year of publication
2001
Pages
41 - 44
Database
ISI
SICI code
0165-2478(200108)78:1<41:EOI1OT>2.0.ZU;2-A
Abstract
Pretreatment with interleukin (IL)-10 inhibited the release of growth-relat ed oncogene GRO-alpha but not of epithelial-cell derived neutrophil activat ing protein (ENA)-78, after injection of lipopolysaccharide (LPS) into heal thy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha and ENA-78 in whole blood and in cultures of isolated po lymorphonuclear and mononuclear cells. (C) 2001 Elsevier Science BN. All ri ghts reserved.