9-HYDROXYCRISAMICIN-A, A NEW CYTOTOXIC ISOCHROMANQUINONE ANTIBIOTIC PRODUCED BY MICROMONOSPORA SP SA246

Authors
YEO WH YUN BS BACK NI KIM YH KIM SS PARK EK WHANG KS YU SH
Citation
Wh. Yeo et al., 9-HYDROXYCRISAMICIN-A, A NEW CYTOTOXIC ISOCHROMANQUINONE ANTIBIOTIC PRODUCED BY MICROMONOSPORA SP SA246, Journal of antibiotics, 50(7), 1997, pp. 546-550
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
7
Year of publication
1997
Pages
546 - 550
Database
ISI
SICI code
0021-8820(1997)50:7<546:9ANCIA>2.0.ZU;2-W
Abstract
9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, w as isolated from a soil microorganism SA246 which was identified as Mi cromonospora sp. The molecular formula of 9-hydroxycrisamicin A was de termined as C32H22O13 based on the HRFAB-MS analysis, and the structur e was determined by various NMR experiments. 9-Hydroxycrisamicin A sho wed weak antimicrobial activity against Gram-positive bacteria and str ong cytotoxic activity against some human cancer cell lines such as SK -OV-3 (ovarian), HCT15 (colon), SK-MEL-2. (melanoma), A549(lung), XF49 8 (central nervous system) with ED50 of 0.47 similar to 0.65 mu g/ml.