1-BETA-METHYL-2-(5-SUBSTITUTED PYRROLIDIN-3-YLTHIO) CARBAPENEMS .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF BO-2502A AND ITS RELATED-COMPOUNDS

Authors
OHTAKE N YAMADA K MANO E OKAMOTO O USHIJIMA R NAKAGAWA S
Citation
N. Ohtake et al., 1-BETA-METHYL-2-(5-SUBSTITUTED PYRROLIDIN-3-YLTHIO) CARBAPENEMS .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF BO-2502A AND ITS RELATED-COMPOUNDS, Journal of antibiotics, 50(7), 1997, pp. 567-585
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
7
Year of publication
1997
Pages
567 - 585
Database
ISI
SICI code
0021-8820(1997)50:7<567:1PC.S>2.0.ZU;2-I
Abstract
The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-subst ituted pyrrolidin-3-ylthio]-6-[(R)- ydroxyethyl]-1-methyl-1-carbapen-2 -em-3-carboxylic acid, in which lactams and cyclic amines are introduc ed as substituents, are described. They showed potent antibacterial ac tivity against Gram-positive and Gram-negative bacteria including P. a eruginosa. Among them, BO-2502A (4h-1) was selected for further evalua tion.