Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist

Authors
Takahashi, N Iwanaga, T Aizawa, H Koto, H Watanabe, K Kishikawa, R Ikeda, T Shoji, S Nishima, S Hara, N
Citation
N. Takahashi et al., Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist, INTERN MED, 40(8), 2001, pp. 791-794
Citations number
8
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
09182918 → ACNP
Volume
40
Issue
8
Year of publication
2001
Pages
791 - 794
Database
ISI
SICI code
0918-2918(200108)40:8<791:AIPIBO>2.0.ZU;2-A
Abstract
A 62-year-old woman treated with pranlukast for 2 months developed intersti tial pneumonitis with a high fever. A lymphocyte stimulation test was react ive to pranlukast. Her clinical symptoms improved with discontinuation of p ranlukast and administration of systemic corticosteroid. To our knowledge, this is the first reported case of drug-induced lung disease involving a le ukotriene. The steps that can be taken to promptly reach a diagnosis and to successfully treat this life-threatening condition are described.