Efficacy and safety of gemifloxacin 320 mg once-daily for 7 days in the treatment of adult lower respiratory tract infections

An open-label, non-comparative study assessed the clinical and bacteriologi cal efficacy of gemifloxacin (320 mg, once-daily for 7 days) in lower respi ratory tract infections (LRTI). Patients with acute exacerbation of chronic bronchitis (AECB, n = 261) or community-acquired pneumonia (CAP, n = 216) were enrolled into the study. Clinical success rates at follow-up (days 21- 28) in the intent-to-treat (ITT) population were high, 83.1% in AECB patien ts (95% CI: 77.9, 87.4) and 82.9% in CAP patients (95% CI: 77.0, 87.5). Hig h bacteriological success rates were achieved (bacteriological ITT populati on), 91.2% (52/57) in AECB patients (95% Cl: 80.0, 96.7) and 77.9% (60/77) in CAP patients (95% CI: 66.8, 86.3). Gemifloxacin was well tolerated with a low incidence of adverse events. Gemifloxacin treatment resulted in high clinical and bacteriological success rates and is a well-tolerated therapy for the treatment of LRTIs. (C) 2001 Elsevier Science B.V. and Internationa l Society of Chemotherapy. All rights reserved.