Mealtime glucose regulation in type 2 diabetes

Glucose control remains the cornerstone of therapeutic strategies designed to reduce the risk of long-term complications in patients with type 2 diabe tes. This article reviews a growing body of evidence suggesting that post-m ealtime glucose spikes may exert an independent effect on diabetic complica tions, and discusses how a more effective strategy requires better focus on the regulation of mealtime glucose. New treatment options, specifically de signed to restore a more physiological post-mealtime insulin profile, may p rovide better tools to ensure more comprehensive glycaemic control, which w ill allow for better prevention of micro- and macrovascular complications i n type 2 diabetic patients.