Formation of antibiotic, biodegradable polymers by processing with IrgasanDP300R (Triclosan) and its inclusion compound with beta-cyclodextrin

Authors
Lu, J Hill, MA Hood, M Greeson, DF Horton, JR Orndorff, PE Herndon, AS Tonelli, AE
Citation
J. Lu et al., Formation of antibiotic, biodegradable polymers by processing with IrgasanDP300R (Triclosan) and its inclusion compound with beta-cyclodextrin, J APPL POLY, 82(2), 2001, pp. 300-309
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science","Material Science & Engineering
Journal title
JOURNAL OF APPLIED POLYMER SCIENCE
ISSN journal
00218995 → ACNP
Volume
82
Issue
2
Year of publication
2001
Pages
300 - 309
Database
ISI
SICI code
0021-8995(20011010)82:2<300:FOABPB>2.0.ZU;2-S
Abstract
The inclusion compound (IC) between the FDA-approved antibacterial Irgasan DP300 (Trichlosan), and beta -cyclodextrin (CD) has been formed. When the I rgasan-beta -CD-IC is embedded in biodegradeable/bioabsorbable films Of pol y(epsilon -caprolactone) (PCL) at low levels (a few wt %), they are rendere d resistant to the growth of E. coli bacteria. When these same PCL films em bedded with Irgasan-beta -CD-IC are used as the adhesive for laminating cot ton fabrics, we observe the resulting cotton laminates to also be resistant to the growth of E. coli bacteria. These results hold promise for the fabr ication of bacteria-resistant polymer films and fibers, as well as antibact erial fabrics, by means of simple melt processing with Irgasan-beta -CD-IC. (C) 2001 John Wiley & Sons, Inc.