Although there have been many proposed etiologies for interface inflammatio
n after laser in situ keratomileusis, the causative factor(s) remains an en
igma. This case of late-onset interface inflammation suggests that the many
previously suspected interface contaminants from the surgical environment
were not involved. Transformation of a previously inert material to an infl
ammatory stimulus is proposed as a potential cause; however, a sample of in
flammatory focus was not obtained because of the immediate and complete res
ponse to frequent topical steroid drops. (C) 2001 ASCRS and ESCRS.