Erythrocyte membrane fluidity changes in psoriasis: an EPR study

The aim of the study was to find the cause of membrane fluidity decrease in psoriasis, observed by other authors, in different types of cells and its clinical consequences. To this end. we have examined the influence of diffe rent clinical and biochemical factors on erythrocyte membrane fluidity chan ges in psoriatic patients. Membrane fluidity was studied by the electron pa ramagnetic resonance spin-labeling method. The data revealed that the decre ase of membrane fluidity corresponded with exacerbation of skin lesions, Th e results clearly indicate that the increased lipid peroxidation may be the essential mechanism of membrane fluidity decrease in psoriasis. (C) 2001 E lsevier Science Ireland Ltd. All rights reserved.