Effect of prepyloric gastric transection and anastomosis on sphincter of Oddi cyclic motility in conscious dogs

Purpose. We previously reported significant changes in sphincter of Oddi cy clic motility after proximal duodenal transection and anastomosis. However, the role of intrinsic myoneural continuity between the antrum and duodenum in this respect is not understood. The aim of this study was to elucidate the effects of prepyloric gastric transection on sphincter of Oddi motility in animals in the conscious state. Methods. Pressures in the bile duct, du odenum, stomach, and sphincter of Oddi and their response to an injection o f cholecystokinin-octapeptide were measured in four conscious dogs, with a duodenal cannula, before and after gastric transection and anastomosis 1.5 cm proximal to the pylorus. Results. Gastric transection did not affect the initiation and propagation of the gastroduodenal migration motor complex. Biliary pressure (5.7 +/- 0.15 to 5.5 +/- 0.2 mmHg; P = 0.91), sphincter of Oddi basal pressure (10.6 +/- 0.3 to 10.7 +/- 0.2 mmHg; P = 0.97), and amp litude (26.0 +/- 1.2 to 32.9 +/- 1.7 mmHg; P = 0.304) did not change after gastric transection. Biliary pressure decreased from phase II to phase III of the duodenal migrating motor complex. Cholecystokinin-octapeptide inhibi ted sphincter of Oddi phasic waves before and after gastric transection. Co nclusions. Intrinsic myoneural transection at the prepyloric region does no t influence sphincter of Oddi cyclic motility. Preservation of pyloroduoden al myoneural continuity in pylorus-preserving gastrectomy would be benefici al to maintain normal sphincter of Oddi motility.