Kinetic form discrimination in Prader-Willi syndrome

Citation
R. Fox et al., Kinetic form discrimination in Prader-Willi syndrome, J INTEL DIS, 45, 2001, pp. 317-325
Citations number
24
Categorie Soggetti
Rehabilitation,"Neurosciences & Behavoir
Journal title
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
ISSN journal
09642633 → ACNP
Volume
45
Year of publication
2001
Part
4
Pages
317 - 325
Database
ISI
SICI code
0964-2633(200108)45:<317:KFDIPS>2.0.ZU;2-A
Abstract
Discrimination of the shape of motion-produced forms generated by random el ements (i.e. second-order stimuli varying in element density and temporal c orrelation) was tested in four groups: (1) subjects with Prader-Willi syndr ome (PWS), chromosome 15q deletion subtype; (2) subjects with PWS, uniparen tal maternal disomy (UPD) subtype; (3) equivalent non-PWS controls; and (4) normal controls. The performance of the normal controls exceeded that of a ll other groups (78% correct, P < 0.009). The PWS deletion (66%) and the eq uivalent control groups (59%) did not differ (P < 0.95). The UPD group perf ormed significantly less well (38%, P < 0.04) than all the other groups. Th e performance of the PWS deletion and equivalent control groups is consiste nt with other data indicating that these populations encounter difficulty m eeting the processing demands posed by second-order stimuli. The inferior p erformance of the UPD group may be attributed to receiving two active allel es of a maternally expressed gene influencing neural development. One candi date is the ubiquitin protein ligase gene (UBE(3)A), which is maternally ex pressed only and localized to the 15q region. Other possibilities include t he requirement of a paternally expressed gene, residual mosaic trisomy 15 i n the brain tissue or complex interactions including specific ratios of dif ferentially spliced gene products.