Regional cerebral blood flow was evaluated by Tc-99m-hexa-methylpropyleneam
ine oxime SPELT in 7 patients (age range, 7-18 y; mean age, 9.1 y) affected
with Behcet's disease and signs or symptoms of central nervous system invo
lvement at different times of their clinical history. Methods: Three patien
ts suffered from seizures, 3 patients were affected with severe persistent
headache that was refractory to common analgesic and nonsteroidal antiinfla
mmatory drugs, and 1 patient had recurrent episodes of acute intracranial h
ypertension. Electroencephalography was performed on all patients, MRI on 5
patients, and CT on 1 patient. Brain SPELT was performed using a high-reso
lution, brain-dedicated camera. After conventional visual analysis by 2 exp
ert readers, 2 transaxial sections were drawn parallel to the bicommissural
line: the first across the thalami and the second across the temporal lobe
at the level of the mesiotemporal structures. Cortical regions of interest
were drawn automatically on the cortical ribbon on the 2 sections; whereas
other regions of interest were drawn by hand around the basal ganglia, the
thalami, and the mesiotemporal structures. Asymmetry analysis was then app
lied, and hypoperfusion was considered when the asymmetry value was >10%. R
esults: Hypoperfusion was observed in all patients by visual and asymmetry
analyses; this finding was localized mainly in the basal ganglia, the thala
mi, and the temporal cortex, including its mesial portion. Temporal hypoper
fusion was found primarily in patients with seizures, and hypoperfusion of
deep gray nuclei was found mainly in the other patients. Electroencephalogr
aphy disclosed brain functional impairment in 5 of 6 patients, whereas MRI
showed multiple bilateral white matter lesions in 1 patient suffering from
persistent headache. Conclusion: As in adults, perfusion SPELT seems to be
very sensitive in disclosing brain abnormalities in children and adolescent
s with Behcet's disease and signs or symptoms of central nervous system inv
olvement, even with negative findings on brain MRI.