Please pass the chips: Genomic insights into obesity and diabetes

Type 2 diabetes mellitus is an increasingly common disorder of carbohydrate and lipid metabolism. Approximately 16 million individuals in the United S tates have diabetes, and 800,000 new cases are identified each year. Two im portant characteristics of this disease are insulin resistance, the failure of peripheral tissues, including liver, muscle, and adipose tissue, to res pond to physiologic doses of insulin, and failure of pancreatic 13-cells to properly secrete insulin in response to elevated blood glucose levels. Obe sity is a significant risk factor for the development of type 2 diabetes me llitus. Recent observations of extremely lean, lipoatrophic models have rev ealed a similar predisposition to developing diabetes. Although it may seem paradoxical that both increased adiposity and severely reduced fat mass ca use diabetes, a common pathophysiologic process in fat may be responsible f or the predisposition to develop hyperglycemia in both conditions. This rev iew will focus on the important role of adipose tissue dysfunction in the p athogenesis of diabetes, and on insights gained through the application of microarray technology to analyze adipocyte gene expression.