The past fifteen years have seen a marked change in the attitude of psychoa
nalysts toward the use of medication in psychoanalysis, yet few detailed ca
se studies have appeared in which the effects of the introduction of a medi
cation on the psychoanalytic process have been studied. A plea for fluoxeti
ne (Prozac) as a weight-loss aid, from a female patient whose analysis had
progressed satisfactorily, set in motion a remarkable series of events. Her
mood brightened, she rapidly lost weight, and she ultimately realized that
she had the fantasy of being impregnated, all of which represented the ree
nactment of crucial childhood experiences. The most significant change in t
he psychoanalytic process was a newfound ability to experience critical tho
ughts and feelings, which previously had been prohibited by her harsh super
ego. At first both patient and analyst believed that the medication had "so
ftened" her superego, but reexamination of the data revealed that most, if
not all, of the changes could be attributed to the transference meaning of
the collaboration rather than to the effects of the drug.