Ac. Baldwin et al., Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthyolder individuals, J GERONT A, 56(8), 2001, pp. M510-M513
Citations number
38
Categorie Soggetti
Public Health & Health Care Science","Medical Research General Topics
Journal title
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Background. Aging is associated with greater susceptibility to muscle injur
y and soreness after exercise. Although elderly persons regularly consume n
onsteroidal anti-inflammatory drugs (NSAIDs), it is not clear that NSAIDs a
lleviate muscle dysfunction and/or inflammation following injurious exercis
e.
Methods. In this double-blind crossover study, 10 men and 5 women (aged 60
+/-2 years, mean SE) consumed naproxen sodium or placebo for 10 days after
performing 64 unilateral eccentric (ECC knee extensions using 75% of the EC
C 1-repetition maximum. Strength was measured before, 3 days after, and 10
days after each bout. Injury and soreness were assessed using magnetic reso
nance images of in. quadriceps femoris (QF) and a visual analog scale.
Results. Three days after exercise, concentric strength loss was greater fo
r placebo (-32 +/-9%) than NSAID (-6 +/-8%; p = .0064). Likewise, isometric
strength declined less for NSAID than placebo (-12 +/-7% vs -24 +/-4%; p =
.0213), and thigh soreness while rising from a chair was greater for place
bo (p less than or equal to .0393) than NSAID (43 +/-7 mm vs 26 +/-7 mm). Q
F cross-sectional area (cm(2)) showing elevated T-2 was 27% and 35% greater
(p less than or equal to .0096) for placebo on Days 3 and 10, respectively
.
Conclusions. Naproxen sodium attenuated muscle injury, strength loss, and s
oreness following ECC exercise in older individuals and may be beneficial d
uring the early stages of increased physical activity.