CONCENTRATIONS OF LYSOSOMAL CYSTEINE PROTEASES ARE DECREASED IN RENAL-CELL CARCINOMA COMPARED WITH NORMAL KIDNEY

Citation
H. Kirschke et al., CONCENTRATIONS OF LYSOSOMAL CYSTEINE PROTEASES ARE DECREASED IN RENAL-CELL CARCINOMA COMPARED WITH NORMAL KIDNEY, Journal of cancer research and clinical oncology, 123(7), 1997, pp. 402-406
Citations number
20
Categorie Soggetti
Oncology
ISSN journal
01715216
Volume
123
Issue
7
Year of publication
1997
Pages
402 - 406
Database
ISI
SICI code
0171-5216(1997)123:7<402:COLCPA>2.0.ZU;2-8
Abstract
Renal cell carcinoma contains significantly lower concentrations of th e lysosomal cysteine proteases, cathepsins B, C, H, L and S, than does normal kidney, as shown by several methods, such as activity determin ation, enzyme-linked immunosorbent assay, immunoblotting and immunohis tochemistry. The same low levels of enzyme activity and concentration have been determined in renal cell carcinoma metastases in the lung. O ur results on the decreased concentration of cysteine peptidases at th e protein level would seem to conflict with earlier results on an incr eased concentration of the cathepsin L mRNA in renal cell carcinoma.