A novel translocation t(2;9)(q14;p12) in AML-M2 with an uncommon phenotype: myeloperoxidase-positive and myeloid antigen-negative

Authors
Specchia, G Mestice, A Storlazzi, TC Anelli, L Pannunzio, A Roberti, MG Rocchi, M Liso, V
Citation
G. Specchia et al., A novel translocation t(2;9)(q14;p12) in AML-M2 with an uncommon phenotype: myeloperoxidase-positive and myeloid antigen-negative, LEUK RES, 25(6), 2001, pp. 501-507
Citations number
29
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
25
Issue
6
Year of publication
2001
Pages
501 - 507
Database
ISI
SICI code
0145-2126(200106)25:6<501:ANTTIA>2.0.ZU;2-V
Abstract
We report a case of acute myeloid leukemia (AML-M2) expressing myeloperoxid ase (MPO) but no myeloid antigens. A few cases with this discordant phenoty pe have been reported and an association has been suggested between the lac k of CD13 and CD33 in MPO positive AML and the presence of t(8:21). Cytogen etic and molecular analyses performed in our case showed 48,XY, + Y, + 8,t( 2;9)(q14;p12). We believe that combined approaches can contribute to detect particular AL cases like the present one. that confirms the heterogeneity of AML, However. further studies are needed to clarify the relationship bet ween phenotypic aberrations and cytogenetic abnormalities. (C) 2001 Elsevie r Science Ltd. All rights reserved.