Shh and Ptc are associated with taste bud maintenance in the adult mouse

Authors
Miura, H Kusakabe, Y Sugiyama, C Kawamatsu, M Ninomiya, Y Motoyama, J Hino, A
Citation
H. Miura et al., Shh and Ptc are associated with taste bud maintenance in the adult mouse, MECH DEVEL, 106(1-2), 2001, pp. 143-145
Citations number
11
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
106
Issue
1-2
Year of publication
2001
Pages
143 - 145
Database
ISI
SICI code
0925-4773(200108)106:1-2<143:SAPAAW>2.0.ZU;2-8
Abstract
In mammals, taste receptor cells are organized into taste buds on tongue. T aste buds are trophically maintained by taste neurons and under continuous renewal, even in adults. We found that the receptor for Sonic hedgehog (Shh ), Patched1 (Ptc), was expressed around taste buds where cells were prolife rating, and that Shh was expressed within basal cells of taste buds. Denerv ation caused the loss of Shh and Ptc expression before the degeneration of taste buds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.