R. Heymann et al., Dynamic expression patterns of the new protocadherin families CNRs and Pcdh-gamma during mouse odontogenesis: comparison with reelin expression, MECH DEVEL, 106(1-2), 2001, pp. 181-184
Protocadherins are transmembrane glycoproteins belonging to the cadherin su
perfamily of molecules, which are involved in many biological processes suc
h as cell adhesion, cytoskeletal organization and morphogenesis. Protocadhe
rins generally exhibit only moderate adhesive activity and are highly expre
ssed in the nervous system. Here, we report on the expression pattern of tw
o novel families of protocadherins (CNRs and Pcdh-gamma) during rodent teet
h development. Furthermore, we compare their expression with that of reelin
, which is the potential ligand of CNRs. Throughout odontogenesis, CNRs, Pc
dh-gamma and reelin show dynamic spatiotemporal expression patterns. which
relate to both morphogenesis and cell differentiation events. (C) 2001 Else
vier Science Ireland Ltd. All rights reserved.