Dynamic expression patterns of the new protocadherin families CNRs and Pcdh-gamma during mouse odontogenesis: comparison with reelin expression

Citation
R. Heymann et al., Dynamic expression patterns of the new protocadherin families CNRs and Pcdh-gamma during mouse odontogenesis: comparison with reelin expression, MECH DEVEL, 106(1-2), 2001, pp. 181-184
Citations number
11
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
106
Issue
1-2
Year of publication
2001
Pages
181 - 184
Database
ISI
SICI code
0925-4773(200108)106:1-2<181:DEPOTN>2.0.ZU;2-4
Abstract
Protocadherins are transmembrane glycoproteins belonging to the cadherin su perfamily of molecules, which are involved in many biological processes suc h as cell adhesion, cytoskeletal organization and morphogenesis. Protocadhe rins generally exhibit only moderate adhesive activity and are highly expre ssed in the nervous system. Here, we report on the expression pattern of tw o novel families of protocadherins (CNRs and Pcdh-gamma) during rodent teet h development. Furthermore, we compare their expression with that of reelin , which is the potential ligand of CNRs. Throughout odontogenesis, CNRs, Pc dh-gamma and reelin show dynamic spatiotemporal expression patterns. which relate to both morphogenesis and cell differentiation events. (C) 2001 Else vier Science Ireland Ltd. All rights reserved.