T. Mohr et al., Insulin action and long-term electrically induced training in individuals with spinal cord injuries, MED SCI SPT, 33(8), 2001, pp. 1247-1252
Purpose: Individuals with spinal cord injuries (SCI) have an increased prev
alence of insulin resistance and type 2 diabetes mellitus. In able-bodied i
ndividuals, training with large muscle groups increases insulin sensitivity
and may prevent type 2 diabetes mellitus. However, individuals with SCI ca
nnot voluntarily recruit major muscle groups, but by functional electrical
stimulation (FES) they can now perform ergometer bicycle training. Methods:
Ten subjects with SCI (35 +/- 2 yr (mean +/- SE), 73 +/- 5 kg, level of le
sion C6-Th4, time since injury: 12 +/- 2 yr) performed 1 yr of FES cycling
(30 min.d(-1). 3 d.wk(-1) (intensive training)). Seven subjects continued 6
months with reduced training (1 d.wk(-1) (reduced training)). A sequential
, hyperinsulinemic (50 mU.min(-1).m(-2) ( step 1) and 480 mU.min(-1).m(-2)
(step 2)), euglycemic clamp, an oral glucose tolerance test (OGTT), and det
ermination of GLUT 4 transporter protein in muscle biopsies were performed
before and after training. Results: Insulin-stimulated glucose uptake rates
increased after intensive training (from 4.9 +/- 0.5 mg.min(-1).kg(-1) to
6.2 +/- 0.6 mg.min(-1).kg(-1) (P < 0.008) (step 1) and from 9.0 +/- 0.8 mg.
min(-1).kg(-1) to 10.6 0.8 mg.min.kg(-1) (P = 0. 103) (step 2)). With the r
eduction in training. insulin sensitivity decreased to a similar level as b
efore training (P > 0,05). GLUT 4 increased by 105% after intense training
and decreased again with the training reduction. The subjects had impaired
glucose tolerance before and after training, and neither glucose tolerance
nor insulin responses to OGTT were significantly altered by training. Concl
usions: Electrically induced bicycle training, performed three times per we
ek increases insulin sensitivity and GLUT 4 content in skeletal muscle in s
ubjects with SCI. A reduction in training to once per week is not sufficien
t to maintain these effects. FES training may have a role in the prevention
of the insulin resistance syndrome in persons with SCI.