Multiple sclerosis (MS) may rarely present as a cerebral mass with the clin
ical features and computed tomography (CT) scan appearance of a cerebral tu
mor. We report a case of MS with large cranial involvement showing a mass e
ffect. We carried out a complete examination, including contrast enhancemen
t, with neuroimaging studies. The operative procedure associated with medic
al treatment was performed and we obtained a good result.