Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

Authors
Peng, H Moffett, J Myers, J Fang, XH Stachowiak, EK Maher, P Kratz, E Hines, J Fluharty, SJ Mizukoshi, E Bloom, DC Stachowiak, MK
Citation
H. Peng et al., Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors, MOL BIOL CE, 12(2), 2001, pp. 449-462
Citations number
53
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR BIOLOGY OF THE CELL
ISSN journal
10591524 → ACNP
Volume
12
Issue
2
Year of publication
2001
Pages
449 - 462
Database
ISI
SICI code
1059-1524(200102)12:2<449:NNSPMA>2.0.ZU;2-K
Abstract
In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF -2) gene through a unique AII-responsive promoter element. Both the type I and type 2 All receptors and the downstream cyclic adenosine 1',3'-monophos phate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, whi ch we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.