An C-flumazenil positron emission tomography (PET) study in a patient with
pallido-pyramidal disease revealed a marked decrease in benzodiazepine-rece
ptor density in the precentral gyros cortex and the mesial frontal cortex.
We suggest that, in addition to dysfunction of basal ganglia-dependent syst
ems, degeneration of the supplementary motor area could also be involved in
the patient's bradykinesia. (C) 2001 Movement Disorder Society.