PX domains: attracted by phosphoinositides

Phosphoinositides recruit proteins to distinct intracellular membranes. Now , the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has been demonstrated to bind phos phoinositides. The interactions of PX-domain-containing proteins with speci fic phosphoinositides are critical for cellular activities such as microbia l killing and membrane trafficking.