Citation
A. Li et Jj. Blow, The origin of CDK regulation, NAT CELL BI, 3(8), 2001, pp. E182-E184
Citations number
14
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392
→ ACNP
Volume
3
Issue
8
Year of publication
2001
Pages
E182 - E184
Database
ISI
SICI code
1465-7392(200108)3:8<E182:TOOCR>2.0.ZU;2-4
Abstract
Cip/Kip proteins that inhibit cyclin dependent kinase 2 (Cdk2) restrain the
initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, X
ic1, is dependent on its recruitment to replication origins. This ensures t
hat activation of Cdk2 and subsequent initiation of replication is co-ordin
ately regulated at, and localized to, replication origins.