The organization of cells and tissues is controlled by the action of 'form-
giving' signalling molecules, or morphogens, which pattern a developmental
field in a concentration-dependent manner. As the fate of each cell in the
field depends on the level of the morphogen signal, the concentration gradi
ent of the morphogen prefigures the pattern of development. In recent years
, molecular genetic studies in Drosophila melanogaster have allowed tremend
ous progress in understanding how morphogen gradients are formed and mainta
ined, and the mechanism by which receiving cells respond to the gradient.