The phosphatidylserine receptor: a crucial molecular switch?

Authors
Henson, PM Bratton, DL Fadok, VA
Citation
Pm. Henson et al., The phosphatidylserine receptor: a crucial molecular switch?, NAT REV MOL, 2(8), 2001, pp. 627-633
Citations number
57
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN journal
14710072 → ACNP
Volume
2
Issue
8
Year of publication
2001
Pages
627 - 633
Database
ISI
SICI code
1471-0072(200108)2:8<627:TPRACM>2.0.ZU;2-1
Abstract
The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the c ollectin family, surface calreticulin and CD91. Clearance of apoptotic cell s, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what th e outcome will be?