Alzheimer's disease and AP toxicity: from top to bottom

Authors
Small, DH Mok, SS Bornstein, JC
Citation
Dh. Small et al., Alzheimer's disease and AP toxicity: from top to bottom, NAT REV NEU, 2(8), 2001, pp. 595-598
Citations number
87
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NATURE REVIEWS NEUROSCIENCE
ISSN journal
14710048 → ACNP
Volume
2
Issue
8
Year of publication
2001
Pages
595 - 598
Database
ISI
SICI code
1471-0048(200108)2:8<595:ADAATF>2.0.ZU;2-7
Abstract
Evidence implicating the beta -amyloid protein (A beta) in the pathogenesis of Alzheimer's disease has steadily accumulated. However, the mechanism by which A beta causes dementia is unknown, Here we argue that a more integra ted, top-down approach to brain function is needed to assess the role of A beta in Alzheimer's disease, and that more attention should be paid to the effects of A beta on synaptic function rather than on cell death.